Muna 2065, Nyika iri pakati pehondo nevamwe vanowedzera-mativi anonzi Nova. Mauto anovandudza uye anodzidzisa Pandoras, vanasikana vanogona kushandisa chaiwo majini matema anonzi Stigmata (Seikon) Kuratidzira masimba epamusoro ekurwisa zvombo uye hunyanzvi. Kutsigira vaPandora varume vanobatana navo vanonzi maLimiters, avo vanoshandisa mamwe masimba "echando" kudzikisira rusununguko rwemakwikwi avo.
Chero yeanogumira aya ndiKazuya Aoi, ane hanzvadzi yekupedzisira aive Pandora. Kazuya anosangana naPandora akasimba, Satellizer el Bridget, akatumidzwa zita rekuti Mambokadzi Asingabatike, pamanyorerwo ake asina hunhu uye nekunyomba kwake zvakanyanya achienda kuWest Genetics Academy kuJapan. Kunyangwe yambiro kubva kune vaanodzidza navo kuti abve paSatellizer, iye ishamwari naKazuya, uye anokumbira kuve iye Limiter. Satellizer inobvuma kushamwaridzana naye, kunyangwe iye achimbowira pamakwikwi erudo anonzi Rana Linchen, uyo anotenda kuti Kazuya ndiye mweya-wake mushure mekumutsigira kuburikidza nehondo zhinji dzakanangana nevapikisi vekoreji vekuchinja chinzvimbo uye makosi Kana veNovas vachirova koreji yavo vachishandisa Pandoras vari pasi pekutonga kwavo kuti vawane mukana ku laboratori yepasi pevhu, makwikwi avo anoiswa.
Satellizer naKazuya vanobatana nevashoma vevadzidzi veWest Genetics kuenda murabhoritari muAlaska, kwavanogona kunge vari kubatsira pamwe neEvolution Pandora (E Pandora) basa, vachibvumira vakadzi vakajairika kutora Stigmata kuisirwa kuve Pandora. Kana mumwe weE Pandoras akaenda berserk, vamwe vacho vanoburitsa kuti mishonga iri mukuyedza haina njodzi here, asi inoitwa kuti iteerere zvishuwo zvesangano rebhizimusi pamwe nemaneja. Pavaona kuti kudzamara zvave kushandiswa, ivo vanofanirwa kushandiswa, iyo E-Pandora Amelia Evans anotungamira kumukira uko kunokwira kuzere paNova Clash.
Kazuya anodzidza zvakawanda nezve zvinongedzo zvemhuri yake kuNova pamwe nePandora. Sekuru vaKazuya Gengo Aoi vakawana iro basa rimwe chete, rinoisa Rana naSatellizer muchikwata chakasarudzika nevakadzi vanonzi Valkyries. Zvakangodaro, panguva yese yekuratidzira chiitiko chakagadzirwa neNova yakasarudzika dhimoni, kunyepedzera kunowanikwa nevePandoras, pamwe neiyo dhumha yeNovas inova yemauto ema100 eNova ayo anopedza maGeneti. Gengo anopikisa izvi nekuburitsa Ngano Pandoras vanova vatete vaKazuya. Iko Chevalier kuyedza kuuraya Gengo achishandisa vasungwa vakati wandei anonzi maBusters, apo vashoma veLegendary Pandoras vanochinja kuva maNovas anouraya, asi basa racho rinodonha.
