Idzo hama dzinoita nzira yakarambidzwa yealchemic yekufambisa kwevanhu mukuyedza kumumutsa apo Trisha anofa nedenda. Nekuda kweizvozvo, iyo transmutation inodzosera kumashure uye mumutemo nekuenzana kuchinjaniswa, gumbo rekuruboshwe nemuviri waAlphonse muviri waEdward waparara. Edward anorasikirwa neruoko rwake rwerudyi kuponesa mweya waAlphonse, achisunga icho chine chisimbiso cheropa muchipfeko chesimbi. Roy Mustang anokoka Edward kuti ave nzira yekudzoresa mutumbi waAlphonse kuti uongororwe neNyika Alchemist. Edward anokunda, achiva iro zita zvinoenderana nemaoko ake eposta, iyo Fullmetal Alchemist.
Makore matatu zvichienda mberi, maElrics anotsvaga iro rinozivikanwa Dombo reMufilosofi kuti aone zvinangwa zvavo. Marwa anotumira zvinyorwa zvake kuti zviwanikwe navo, zvisinei ivo vanodzidza chinhu chakakosha kuita kuti Dombo iri zvibayiro zvevanhu. Shamwari yaMu Mustang, Maes Hughes, anoita ongororo yavo, asi akapfurwa akafa negodo rakavanzika rekutsvaga mazano eHomunculi.
Kuona naIzumi, maElrics anodzidza kushandurwa kwevanhu kwakaitwa naiye pamwana wake akazvarwa akafa. Hunyanzvi hunhu Huchi hunotora Alphonse, asi hunoponeswa nemutungamiri weAmestris Mambo Bradley, anoratidzwa kushanda saHomunculus Hasha. Makaro anonyungudutswa pasi nekudzokororwazve mukati mekutanga Baba veHomunculi. Winry nemaElric anodzokera kuCentral City kuti vaende naHughes asi vadzidze nezvekupfuura kwake. Lieutenant Maria Ross akagadzirirwa kuuraya kwaHughes, asi zviri pachena kuti akaurayiwa naMustang. Asi, Edward anodzidza kuti kuenda kwaRoss kwakarongedzwa kuitira kuti aendeswe pachivande naMustang kubva kuUnited States kuenda kuXing, achibatsirwa naXingese muchinda Ling Yao. Hohenheim akabatanidzwazve naEdward asi anomushora nekuda kwekusavapo kwenguva refu achigara.
Sezvo rondedzero inofambira mberi, maHomunculi anosangana neve protagonists kakawanda. Mustang inouraya ruchiva; Mustang naLing vanotora Makaro, zvisinei anozopedzisira adya Shanje mune yake null, uye Edward, Ling-kunge dumbu. Makaro anotora Alphonse kunosangana naBaba, asi Ling anoshanduka akananga kuva homunculus, kunyanya avatar yechinyowani, apo vamwe vanotiza kubva mudumbu reGluttony. VaElrics vanoburitswa kuti vaenderere mberi nebasa ravo chero Baba vasingapikiswe navo.
Kuwana mugero wepasi pevhu pazasi paBriggs, General Olivier Armstrong vanowana Baba uye maElrics vanga vachigadzira boka rekushambadzira renyika uye rinotarisira kupa vagari varo kuti vakwanise kukwira huMwari. Makaro anopora anotengesa Baba nezvirangaridzo zvavo zvekare, vachibatana pamwe mushure, naEdward, chimera minion veKimblee Hohenheim. Hohenheim anozivisa kuvanakomana vake mumwe nemumwe kuti haasi kufa, akashanduka kuita dombo rehupenyu reFilosofi naBaba makore mazana mana kumashure.
Zuva reChipikirwa rinosvika uye Baba vanogadzirira kutanga zano ravo rekuora uye avo vakaedza kutapurirana kwevanhu sezvibayiro zvavo izvo zvakakosha. Iwo akasiyana protagonists anopesana nevanababa vababa, neese Homunculi achipera. Kuteedzera kumanikidzwa Mustang, pamwe neveElrics, Izumi, Hohenheim inounganidzwa sezvikonzero baba vanomutsa kutenderera kwenyika. Zvakangodaro, Scar neHohenheim vanoita kuti maAmestria aponeswe nematanho. Makaro anoparadzwa naFata, kunyangwe baba vakatarisana pamusoro pevhu apo ma protagonists anomurwisa kuti apfeke Dombo rake reMuzivi.
Alphonse, ane nhumbi dzokurwa nadzo dzakangoparadzwa kuburikidza nehondo yekupedzisira yakanangana naBaba, anopa mweya wake kuti awanezve ruoko rwerudyi, uyo anoparadza Dombo raBaba, achimudzosera kuGedhi reEchokwadi raEdward. Edward anorasikirwa nesimba rake kuita alchemy kupora mweya nemuviri waAlphonse. Hohenheim anoona guva kwaanofa aine grin yaTrisha.
